INVESTIGATION THE EFFECT OF HYPOTHYROIDISM ON HEMATOLOGICAL PARAMETERS
Aim: To investigate impact of the hypothyroidism on hematological parameters.
Material and Method: Twenty patients with hypothyroidism and twenty two healthy subjects were enrolled in this study between February 2015 and July 2015. We collected clinical and laboratory data of patients with hypothyroidism and randomized healthy subject’s from the Adıyaman University Medical Faculty Hospital records retrospectively. The patients with anemia, rheumatic diseases, chronic kidney diseases, chronic liver diseases, chronic obstructive pulmonary disease, chronic heart diseases, inflammatory bowel diseases, malignancy and acute infections were excluded from the study. Patients were divided into two groups; hypothyroid group and healthy group. TSH values were increased in all of the hypothyroid patients. We compared hematological parameters consist of hemoglobin, platelet count, white blood cell (WBC), red cell distribution width (RDW) and mean platelet volume (MPV) between the two groups.
Results: 70% of patients with hypothyroidism were female and 30% of patients were male. Mean age of patients with hypothyroidism were 44,8±13,4. 72,7% of healthy subjects were female and 27,3% of healthy subjects were male. Mean age of healthy subjects was 31±14,6. In the result with Independent sample T test increased RDW-CV values was significantly associated with hypothyroidism (P value =0.01). The other hematological parameters weren’t different between the groups (P value >0.05).
Conclusion: The present study demonstrated that increased RDW values was associated with hypothyroidism.
Key words: Hypothyroidism, RDW, MPV
Tam metin:PDF (English)
Kawa MP, Grymula K, Paczkowska E, Baskiewicz-Masiuk M, Dabkowska E, Koziolek M et al., Clinical relevance of thyroid dysfunction in human haematopoiesis: biochemical and molecular studies. Eur J Endocrinol. 2010:295-305.
Fein HG, Rivlin RS. Anemia in thyroid diseases. Med Clin North Am. 1975:1133-45.
Dorgalaleh A, Mahmoodi M, Varmaghani B, Kiani Node F, Saeeidi Kia O, Alizadeh Sh et al., Effect of thyroid dysfunctions on blood cell count and red blood cell indice. Iran J Ped Hematol Oncol. 2013:73-7.
Bashir H, Bhat MH, Farooq R, Majid S, Shoib S, Hamid R et al., Comparison of hematological parameters in untreated and treated subclinica hypothyroidism and primary hypothyroidism patients. Med J Islam Repub Iran. 2012:172-8.
Simel DL. Is the RDW-MCV classification of anaemia useful? Clin Lab Haematol. 1987:349-59.
Sultana GS, Haque SA, Sultana T, Ahmed AN. Value of red cell distribution width (RDW) and RBC indices in the detection of iron deficiency anemia. Mymensingh Med J. 2013:370-6.
Bessman JD, Gilmer PR Jr, Gardner FH. Too early to put down RDW for discriminating iron deficiency and thalassemia. Am J Clin Pathol. 1986:693-5.
Kim DS, Shin D, Jee H, Kim TG, Kim SH, Kim do Y et al., Red blood cell distribution width is increased in patients with psoriasis vulgaris: A retrospective study on 261 patients. J Dermatol. 2015:567-71.
Li W, Li X, Wang M, Ge X, Li F, Huang B et al., Association between red cell distribution width and the risk of heart events in patients with coronary artery disease. Exp Ther Med. 2015:1508-1514.
Ay S, Eryilmaz MA, Aksoy N, Okus A, Unlu Y, Sevinc B. Is early detection of colon cancer possible with red blood cell distribution width? Asian Pac J Cancer Prev. 2015:753-6.
Mahmood NA, Mathew J, Kang B, De Bari VA, Khan MA. Broadening of thered blood cell distribution width is associated with increased severity of illness in patients with sepsis. Int J Crit Illn Inj Sci. 2014:278-82.
Yu HM, Park KS, Lee JM. The value of red blood cell distribution width in subclinical hypothyroidism. Arq Bras Endocrinol Metabol. 2014:30-6.
Montagnana M, Lippi G, Targher G, Salvagno GL, Guidi GC. The red blood cell distribution width is associated with serum levels of thyroid stimulating hormone in the general population. Int J Lab Hematol. 2009:581-2.
Aktas G, Sit M, Dikbas O, Tekce BK, Savli H, Tekce H et al., Could red cell distribution width be a marker in Hashimoto's thyroiditis? Exp Clin Endocrinol Diabetes. 2014;122(10):572-4.
Kim JH, Park JH, Kim SY, Bae HY. The mean platelet volume is positively correlated with serum thyrotrop in concentrations in a population of healthy subjects and subjects with unsuspected subclinical hypothyroidism. Thyroid. 2013;23(1):31-7.
Yilmaz H, Ertuğrul O, Ertuğrul B, Ertuğrul D. Mean platelet volume in patients with subclinical hypothyroidism. Platelets. 2011;22(2):143-7.
Lippi G, Danese E, Montagnana M, Nouvenne A, Meschi T, Borghil. Mean platelet volume is significantly associated with serum levels ofthyroid-stimulating hormone in a cohort of older eu thyroid subjects.Endocr Res. 2015;40(4):227-30.
This work is licensed under a Creative Commons Attribution 4.0 License.